Soman exposure induces performance deficits in tests of vestibular motor function, exploratory activity, spatial memory and fear conditioning in rats

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Title

Soman exposure induces performance deficits in tests of vestibular motor function, exploratory activity, spatial memory and fear conditioning in rats

Identifier

TSU2010Schultz

Type

["Text"]

Genre

["Theses"]

Format

["pdf"]

Rights

This thesis or dissertation is restricted from access because there is no internet release form on file. If you are the author and you would like to submit an internet release form allowing us to publish your thesis or dissertation online, please contact spcoll@towson.edu. Copyright protected, all rights reserved.

General Notes

Thesis research directed by Department of Psychology.

Extent

ix, 87 pages

Language

["English"]

Repository

["Towson University. Albert S. Cook Library. Special Collections and University Archives"]

Collection Name

["Towson University Graduate Theses and Dissertations"]

Author

Schultz, Mark K.;

Degree Date

2010

Department or Program

["Towson University. Department of Psychology"]

Abstract

A battery of behavioral tests was used to evaluate the cognitive and motor deficits induced by exposure to the nerve agent soman (GD) in rats. We replicated our previous findings of home cage hyperactivity, transient impairment in locomotor coordination on a balance beam, impairment in spatial memory acquisition in the Morris water maze, and reduced freezing behavior in a fear conditioning paradigm. In addition to replicating our previous findings, we assessed the Barnes maze test of spatial memory and the light dark box test of anxiety for sensitivity to the effects of GD-exposure. The GD-exposed group demonstrated significant performance deficits in ability to complete the Barnes maze task; however some measurements taken suggest that these deficits may be independent of spatial memory impairment. In the light dark box, GD-exposed rats displayed increased time on the light side, which may suggest decreased aversion to the light at the time of test.

Thesis Committee Members

["Rockwood, Gary","Lumley, Lucille"]

Date Published

01 November 2013

Author (Controlled)

["Schultz, Mark Kendall, Jr."]

Thesis Advisor

["Parente, Frederick","Chachich, Mark"]

Degree Note

(M.A.) -- Towson University, 2010.

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